Midnight In The Desert

[Dr. MD MD]

Now all the cool doctors vape.

Honestly, I have a vape unit but I still prefer smoking weed. Sigh...just don't start kids. Don't be like me.

[DanTSX]

Art went through her ethnicity. I don’t remember all the components but I vaguely remember Hawaiian, Jamaican, Filipina and some anglo component like Irish.

What a mutt


Le 56% face

[DanTSX]

Honestly, I have a vape unit but I still prefer smoking weed. Sigh...just don't start kids. Don't be like me.

Edibles > smoking

[Theadora]

Honestly, I have a vape unit but I still prefer smoking weed. Sigh...just don't start kids. Don't be like me.

Weed is non toxic, and the resins don't cause the problems that tobacco tar does, but nicotine is poison, tar or no tar.  Kids ought to be allowed to smoke all the dope they can handle, and still maintain well enough to meet at school, to skip out and go party, like we always used to do.

[DanTSX]

I think thats why Ramonas voice disappeared on KNYE long ago
Except it was Arts cage who's was rattled

Smokers have nice voices oftentimes.

That’s why Bowie never quit and why his voice evolved over the decades

[Dr. MD MD]

Edibles > smoking

I like doing those once in awhile too but it's a much heavier hit, as I'm sure you know. So, I don't always have the time to get that messed up. Funny, I just made some butter last night though.

[DanTSX]

he had tits so he was half way there--oh transhumanism. oops.

You didn’t take the college path huh?

[DanTSX]

I like doing those once in awhile too but it's a much heavier hit, as I'm sure you know. So, I don't always have the time to get that messed up. Funny, I just made some butter last night though.

When you can buy it retail, and know it’s the content, it’s much easier to control the dose.


I used to abhor edibles because they would KO me.  Now that I can buy retail, they are my bestie

[Dr. MD MD]

When you can buy it retail, and know it’s the content, it’s much easier to control the dose.


I used to abhor edibles because they would KO me.  Now that I can buy retail, they are my bestie

Yeah, maybe next time I'm at the dispensary I'll give something like that a shot too.

[Yorkshire pud]

Weed is non toxic, and the resins don't cause the problems that tobacco tar does, but nicotine is poison, tar or no tar.  Kids ought to be allowed to smoke all the dope they can handle, and still maintain well enough to meet at school, to skip out and go party.

Cannabis burns hotter than tobacco. Causing the lungs to deal with it. And taken regularly before the age of about 23-24 can cause the frontal cortex to not fuse. This means that the brain doesn't develop correctly preventing it from reasoning the way adults do.. It's why we look back and wonder how the hell we thought it was a good idea climbing a 100 foot tree when we were kids, as adults it looks stupid. That isn't just fear or lack of ability, it's our reasoning.

[Richard Groyper]

You didn’t take the college path huh?

i tried. i really did.

[Dr. MD MD]

Cannabis burns hotter than tobacco. Causing the lungs to deal with it. And taken regularly before the age of about 23-24 can cause the frontal cortex to not fuse. This means that the brain doesn't develop correctly preventing it from reasoning the way adults do.. It's why we look back and wonder how the hell we thought it was a good idea climbing a 100 foot tree when we were kids, as adults it looks stupid. That isn't just fear or lack of ability, it's our reasoning.

Show your work.

[popple]

And airplanes had those little ashtrays in the armrests.

I flew Philippine Airlines in the last few years and the plane I took still had ashtrays in the armrests.

[Yorkshire pud]

Show your work.

Hey, I don't give a shit what you think. If you're interested you can look it up yourself. But I'll be generous.

https://www.sciencedirect.com/science/article/pii/S1878929315000699

Participants included 33 cannabis users and 35 controls (ages 18â€"25). Exclusions included co-morbid psychiatric/neurologic disorders and heavy other drug use. Multiple regressions and Pearson r correlations examined the effects of cannabis use on gyrification, SA and cognition.

Results
Cannabis use was associated with decreased gyrification in: ventral-medial PFC (RH: [FDR corrected p = .02], LH: [FDR corrected p = .02]); medial PFC (RH: [FDR corrected p = .02], LH: [FDR corrected p = .02]); and frontal poles (RH: [FDR corrected p = .02], LH: [FDR corrected p = .02]). No differences were observed in bilateral hemispheres, PFC, dorsolateral, ventrolateral, or inferior parietal ROIs. Cannabis use was associated with marginally decreased SA in left: medial PFC [FDR corrected p = .09], and ventral lateral PFC: [FDR corrected p = .09]. In cannabis users, increased gyrification was associated with improved working-memory performance in right medial (p = .003), ventral-medial (p = .03), and frontal pole ROIs (p = .007).

Conclusions
Cannabis use was associated with reduced gyrification in PFC regions implicated in self-referential thought and social cognition. Results suggest that these gyrification characteristics may have cognitive implications.

https://www.ncbi.nlm.nih.gov/pubmed/11711246

This study examined the neurophysiological effects of cannabis. Cerebral blood flow (CBF) was measured in 12 long-term cannabis users shortly after cessation of cannabis use (mean 1.6 days). The findings showed significantly lower mean hemispheric blood flow values and significantly lower frontal values in the cannabis subjects compared to normal controls. The results suggest that the functional level of the frontal lobes is affected by long-term cannabis use.

[Faustina]

Art's chain smoking probably killed Ramona, to be honest. You can't smoke around an asthma sufferer.

Ramona herself was a chain-smoker.  Hoagie mentioned this on his Art Bell Tribute show. 

[Dr. MD MD]

Hey, I don't give a shit what you think. If you're interested you can look it up yourself. But I'll be generous.

https://www.sciencedirect.com/science/article/pii/S1878929315000699

Participants included 33 cannabis users and 35 controls (ages 18â€"25). Exclusions included co-morbid psychiatric/neurologic disorders and heavy other drug use. Multiple regressions and Pearson r correlations examined the effects of cannabis use on gyrification, SA and cognition.

Results
Cannabis use was associated with decreased gyrification in: ventral-medial PFC (RH: [FDR corrected p = .02], LH: [FDR corrected p = .02]); medial PFC (RH: [FDR corrected p = .02], LH: [FDR corrected p = .02]); and frontal poles (RH: [FDR corrected p = .02], LH: [FDR corrected p = .02]). No differences were observed in bilateral hemispheres, PFC, dorsolateral, ventrolateral, or inferior parietal ROIs. Cannabis use was associated with marginally decreased SA in left: medial PFC [FDR corrected p = .09], and ventral lateral PFC: [FDR corrected p = .09]. In cannabis users, increased gyrification was associated with improved working-memory performance in right medial (p = .003), ventral-medial (p = .03), and frontal pole ROIs (p = .007).

Conclusions
Cannabis use was associated with reduced gyrification in PFC regions implicated in self-referential thought and social cognition. Results suggest that these gyrification characteristics may have cognitive implications.

https://www.ncbi.nlm.nih.gov/pubmed/11711246

This study examined the neurophysiological effects of cannabis. Cerebral blood flow (CBF) was measured in 12 long-term cannabis users shortly after cessation of cannabis use (mean 1.6 days). The findings showed significantly lower mean hemispheric blood flow values and significantly lower frontal values in the cannabis subjects compared to normal controls. The results suggest that the functional level of the frontal lobes is affected by long-term cannabis use.

Already skeptical because of the incedibly low sample rate but let's find out who's sponsoring this study, shall we?

Yeah, NIDA has been at this since they first outlawed weed.

Check out Controversial research.

https://en.wikipedia.org/wiki/National_Institute_on_Drug_Abuse

[Yorkshire pud]

Ramona herself was a chain-smoker.  Hoagie mentioned this on his Art Bell Tribute show.

I bet her dying with an asthma attack was unpleasant.

[Yorkshire pud]

Already skeptical because of the incedibly low sample rate but let's find out who's sponsoring this study, shall we?

As I say, I don't give a shit what you think.

Nature Magazine..Sorry it isn't an Alex Jones or the hippy video. And it has big words in it.

https://www.nature.com/articles/s41598-017-11645-8

Chronic adolescent marijuana use has been linked to the later development of psychiatric diseases such as schizophrenia. GABAergic hypofunction in the prefrontal cortex (PFC) is a cardinal pathological feature of schizophrenia and may be a mechanism by which the PFC loses its ability to regulate sub-cortical dopamine (DA) resulting in schizophrenia-like neuropsychopathology. In the present study, we exposed adolescent rats to Δ-9-tetra-hydrocannabinol (THC), the psychoactive component in marijuana. At adulthood, we characterized the functionality of PFC GABAergic neurotransmission and its regulation of sub-cortical DA function using molecular, behavioral and in-vivo electrophysiological analyses. Our findings revealed a persistent attenuation of PFC GABAergic function combined with a hyperactive neuronal state in PFC neurons and associated disruptions in cortical gamma oscillatory activity. These PFC abnormalities were accompanied by hyperactive DAergic neuronal activity in the ventral tegmental area (VTA) and behavioral and cognitive abnormalities similar to those observed in psychiatric disorders. Remarkably, these neuronal and behavioral effects were reversed by pharmacological activation of GABAA receptors in the PFC. Together, these results identify a mechanistic link between dysregulated frontal cortical GABAergic inhibition and sub-cortical DAergic dysregulation, characteristic of well-established neuropsychiatric endophenotypes.


Heather Wade is a heavy weed smoker isn't she?

[Taco Bell]

Cannabis burns hotter than tobacco. Causing the lungs to deal with it. And taken regularly before the age of about 23-24 can cause the frontal cortex to not fuse. This means that the brain doesn't develop correctly preventing it from reasoning the way adults do.. It's why we look back and wonder how the hell we thought it was a good idea climbing a 100 foot tree when we were kids, as adults it looks stupid. That isn't just fear or lack of ability, it's our reasoning.

Bongs with ice water for the win.
Pullin those frosty tubes

[SergeantMajor]

So, what is the latest with HW and MiTD? Is she quitting for good this time?

Thanks

[Dr. MD MD]

As I say, I don't give a shit what you think.

but I thought you were all scientific like?!

[aldousburbank]

Hey, I don't give a shit what you think. If you're interested you can look it up yourself. But I'll be generous.

https://www.sciencedirect.com/science/article/pii/S1878929315000699

Participants included 33 cannabis users and 35 controls (ages 18â€"25). Exclusions included co-morbid psychiatric/neurologic disorders and heavy other drug use. Multiple regressions and Pearson r correlations examined the effects of cannabis use on gyrification, SA and cognition.

Results
Cannabis use was associated with decreased gyrification in: ventral-medial PFC (RH: [FDR corrected p = .02], LH: [FDR corrected p = .02]); medial PFC (RH: [FDR corrected p = .02], LH: [FDR corrected p = .02]); and frontal poles (RH: [FDR corrected p = .02], LH: [FDR corrected p = .02]). No differences were observed in bilateral hemispheres, PFC, dorsolateral, ventrolateral, or inferior parietal ROIs. Cannabis use was associated with marginally decreased SA in left: medial PFC [FDR corrected p = .09], and ventral lateral PFC: [FDR corrected p = .09]. In cannabis users, increased gyrification was associated with improved working-memory performance in right medial (p = .003), ventral-medial (p = .03), and frontal pole ROIs (p = .007).

Conclusions
Cannabis use was associated with reduced gyrification in PFC regions implicated in self-referential thought and social cognition. Results suggest that these gyrification characteristics may have cognitive implications.

https://www.ncbi.nlm.nih.gov/pubmed/11711246

This study examined the neurophysiological effects of cannabis. Cerebral blood flow (CBF) was measured in 12 long-term cannabis users shortly after cessation of cannabis use (mean 1.6 days). The findings showed significantly lower mean hemispheric blood flow values and significantly lower frontal values in the cannabis subjects compared to normal controls. The results suggest that the functional level of the frontal lobes is affected by long-term cannabis use.

You say that like it's a bad thing.

[Richard Groyper]

So, what is the latest with HW and MiTD? Is she quitting for good this time?

Thanks

she gets closer every day.

[Dr. MD MD]

As I say, I don't give a shit what you think.

Nature Magazine..Sorry it isn't an Alex Jones or the hippy video. And it has big words in it.

https://www.nature.com/articles/s41598-017-11645-8

Chronic adolescent marijuana use has been linked to the later development of psychiatric diseases such as schizophrenia. GABAergic hypofunction in the prefrontal cortex (PFC) is a cardinal pathological feature of schizophrenia and may be a mechanism by which the PFC loses its ability to regulate sub-cortical dopamine (DA) resulting in schizophrenia-like neuropsychopathology. In the present study, we exposed adolescent rats to Δ-9-tetra-hydrocannabinol (THC), the psychoactive component in marijuana. At adulthood, we characterized the functionality of PFC GABAergic neurotransmission and its regulation of sub-cortical DA function using molecular, behavioral and in-vivo electrophysiological analyses. Our findings revealed a persistent attenuation of PFC GABAergic function combined with a hyperactive neuronal state in PFC neurons and associated disruptions in cortical gamma oscillatory activity. These PFC abnormalities were accompanied by hyperactive DAergic neuronal activity in the ventral tegmental area (VTA) and behavioral and cognitive abnormalities similar to those observed in psychiatric disorders. Remarkably, these neuronal and behavioral effects were reversed by pharmacological activation of GABAA receptors in the PFC. Together, these results identify a mechanistic link between dysregulated frontal cortical GABAergic inhibition and sub-cortical DAergic dysregulation, characteristic of well-established neuropsychiatric endophenotypes.

Read the controversial reasearch section.

https://en.wikipedia.org/wiki/National_Institute_on_Drug_Abuse

[aldousburbank]

So, what is the latest with HW and MiTD? Is she quitting for good this time?

Thanks

Hey don't derail this thread. We're talking about weed and junk right now.

[Yorkshire pud]

Read the controversial reasearch section.

https://en.wikipedia.org/wiki/National_Institute_on_Drug_Abuse

All science is controversial, it doesn't make it wrong..

[GravitySucks]

I bet her dying with an asthma attack was unpleasant.

It seemed to be for Art.

[Dr. MD MD]

All science is controversial, it doesn't make it wrong..

In this case it does.

[ItsOver]

Hey don't derail this thread. We're talking about weed and junk right now.

Ha!  Can we get back to the medical assessment of Art's tits?

[WhiteCrow]

Cannabis burns hotter than tobacco. Causing the lungs to deal with it. And taken regularly before the age of about 23-24 can cause the frontal cortex to not fuse. This means that the brain doesn't develop correctly preventing it from reasoning the way adults do.. It's why we look back and wonder how the hell we thought it was a good idea climbing a 100 foot tree when we were kids, as adults it looks stupid. That isn't just fear or lack of ability, it's our reasoning.

Matches up with my personal observations, decades later of kids that started daily pot usage when 12 to 14 years old. Always noticing that older life long daily pot users are having optic nerve and other eye problems.